A plane carrying a family home to Mexico from Philadelphia was involved in a fatal crash Friday night.

The family, including a mom and her daughter, were travelling to Mexico after a life-saving medical treatment in the States. Tragically, the aircraft crashed around 30 seconds after take off.

Along with the mother and daughter, onboard the plane were four crew members, all of which feared dead.

The Learjet 55 was expected to head towards Missouri before flying to what was supposed to be its final destination, Tijuana.

Unfortunately, Jet Rescue Air Ambulance, which operated the plane that crashed, released a statement, writing, “We cannot confirm any survivors.

“When an incident like this happens, it’s shocking and surprising,” the spokesperson said further.

“All of the aircraft are maintained, not a penny is spared because we know our mission is so critical.”

Footage from cameras near the area showed a large fireball erupting, which engulfed several homes and vehicle and left several people injured. As per reports, some were taken to the hospital for further treatment.

Josh Shapiro, Pennsylvania governor, warned that fatalities in the crash were to be expected, saying: “We know that there will be loss.” He described the tragic Philadelphia plane crash an “awful aviation disaster.”

President Trump released a statement, saying the Philadelphia plane crash was “so sad.”

“More innocent souls lost. Our people are totally engaged,” the statement added.

The response was massive, and people are warned to stay away from Northeastern Philadelphia neighborhood.

As per The Sun, the final words of the pilot flying the plane after the control tower directed it towards airspace, were: “one, two, three point eight, mike tango sierra, zero, five six, medivac, thank you. Have a good day.”

The air controller who tried to stay in touch realized something wasn’t right.

“We have a lost aircraft, we are not exactly sure what has happened so we’re still trying to figure it out for now,” he said, as per The Sun.

“The field is going to be closed, so no in-bounds or out-bounds probably.”

This accident came in the wake of one of the deadliest US air disasters that happened on Wednesday, January 29, when the American Airlines jet collided with a US military helicopter with 64 passengers on board.